Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06292897

Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and non-severely overweight/normoweight (BMI < 27.5) patients affected by prostate carcinoma.

ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.

iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Prostate Cancer Body Weight Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Prostate Adenocarcinoma Prostate Neoplasm Prostatic Diseases Prostatic Neoplasm Prostatic Neoplasms Signs and Symptoms Urogenital Diseases Urogenital Neoplasms

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

IRCCS Cà Granda Ospedale Maggiore Policlinico Milano

Milan, Italy

Location status: Recruiting

Location contact

giancarlo albo, MD

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • affected by prostate cancer

Exclusion criteria

-

Treatment and study plan

observational study

Other

observational study

Primary outcomes

  1. Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma

    Time frame: 4 years

Study contacts

Contact information is provided by the study sponsor or research team.

Giancarlo Albo, MD,

CONTACT

[email protected]

00390255034501

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Other

Collaborators

  • National Research Council

Registry information

Official study title

Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression

Acronym: OBESITA'&PCa

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Mar 5, 2024
Registry last updated
Mar 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.