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OpenTrials
Active, Not Recruiting

NCT Number: NCT06407648

Using Personalized Assessments in the Treatment of Childhood OCD

The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents. The investigators will also examine whether personalized cognitive-behavioral therapy (CBT) that is informed by personalized OCD assessments yields better clinical outcomes when compared to standard CBT for youth with OCD

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Obsessive-Compulsive Disorder Anxiety Disorders Mental Disorders

Age range

8 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • be 8-17 years of age;
  • meet diagnostic criteria for a primary diagnosis of OCD on a structured clinical interview;
  • have moderate OCD severity as evidenced by a CY-BOCS total score of ≥16;
  • medication free and/or on a stable dose of medication 8 weeks prior to study participation;
  • be English speaking.

Exclusion criteria

  • the presence of psychotic disorder, bipolar disorder, or autism spectrum disorders;
  • significant suicidal ideation that warrants medical intervention;
  • concurrent psychotherapy for OCD;
  • inability to complete scales, or attend visits.

Treatment and study plan

Personalized Assessments

Other

Personalized CBT will use individualized OCD symptom networks to guide CBT strategies to target central symptom nodes in contemporaneous networks.

Standard of care

Other

The standard CBT condition will use standard-of-care approaches to guide CBT strategies to target OCD symptoms.

Primary outcomes

  1. Children's Yale-Brown Obsessive-Compulsive Scale Second Edition (CY-BOCS-II) Total Severity Score

    Time frame: Screen, Baseline (Week 0), Week 4, Week 8, and Week 12

    A clinician-rated measure of OCD symptom severity in the past week. This 10-item measure is rated on a 0 to 5 scale with a total score ranging from 0 to 50. A higher total score is reflective of greater OCD symptom severity.

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 9, 2024
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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