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Completed

NCT Number: NCT00584168

Using Dexamethasone After Uvulopalatopharyngoplasty

This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).

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Key information

Conditions

Pain Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

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About this study

The study was designed because patients have a lot of pain after they have a UPPP. Certain drugs called steroids may lessen the pain associated from this surgery. This study uses Dexamethasone (a corticosteroid), to see if it will help reduce pain, decrease the amount of time until the patient can begin to eat or return to normal activity, or increase their satisfaction with pain management. In this study the patients will be randomized (computer chosen) to receive either the study drug (dexamethasone), or a placebo. The patient will start the day before surgery with a single pill. They will then receive the dexamethasone or a placebo twice daily for the next four days and then once daily for the next two days for a total of seven days. Afterward, they will be asked to complete a questionnaire. The five questions ask patients to access the amount of pain they have, how much of their normal diet or activity they have returned to, and how much pain medication they have taken. At the next follow-up visit they will be asked to complete another questionaire (9 questions) about the patient's satisfaction with pain management.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Candidates scheduled for UPPP surgery.
  • Able to take steroids

Exclusion criteria

  • Those patients who unable to take steroids

Treatment and study plan

Dexamethasone

Drug

They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.

Placebo

Drug

They will take a pill the day before surgery, twice daily for the next four days and then once daily for the next two days for a total of seven days.

Primary outcomes

  1. Quantifying patient treatment with a questionaire. Patient will rate their satisfaction with pain management.

    Time frame: Eleven days post-operative

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Official study title

Decreasing Morbidity After Uvulopalatopharyngoplasty With the Use of Dexamethasone - A Randomized Double Blinded Placebo Controlled Trial

Important dates

Study start
2005
Primary completion
2011
Study completion
2011
First posted
Jan 2, 2008
Registry last updated
Feb 2, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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