Using Artificial Intelligence-based ChatBot to Improve Women's Participation to Cervical Cancer Screening Programme

Primary outcomes

1. HPV self-sampling "return" rate

   Time frame: 1 year after postal mail

   Percent of women recalled who "return" HPVss over 12 months "Return" means: 1) the receipt of the vaginal self-sample at the laboratory; 2) the performance of clinician-collected HPV testing for those who prefer to be screened by a health professional; and 3) Information about a recent screening or a cervical screening exclusion reason.

2. Proportion of HPVss-positive women "well managed"

   Time frame: 1 year after postal mail

   Percent of recruited women well managed (Percent of women screened and completing full pathway of HPV screening and treatment over 12 months).

   "Well managed" is defined as: completed a valid screening test (sample processed successfully to positive or negative result, including recollection of invalid samples) AND

   • for HPV negative women, woman advised of negative result
   • for HPV positive women, completed assessment.

3. Cost and cost-efficacy

   Time frame: Month 36 - Month 48

   Costs will be estimated using an ingredients approach whereby resources used for the respective interventions are identified and valued. The incremental cost-effectiveness ratios (ICERs) will be calculated as the mean difference in total costs between the intervention groups with the mean difference in effects, and expressed as both euros and US dollars per percentage change in screening participation.