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NCT Number: NCT07276633

Use of Subanesthetic Dose Propofol Before Extubation

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

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Key information

Conditions

Emergence Agitation Behavior Confusion Delirium Emergence Delirium Health Behavior Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Patient Satisfaction Postoperative Complications Rhinoplasty Signs and Symptoms Treatment Adherence and Compliance

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yuzuncu Yil University, Dursun Odabas Medical Center

Van, 65080, Turkey (Türkiye)

About this study

This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages 18-65 years
  • Patients scheduled for rhinoplasty surgery
  • ASA physical status I-II
  • No respiratory tract infection
  • Provided written informed consent

Exclusion criteria

  • Refusal to participate
  • Presence of any respiratory tract infection
  • Younger than 18 or older than 65
  • ASA III-IV
  • Known allergy to study medications
  • Predicted difficult intubation

Treatment and study plan

Propofol (Sub-Anesthetic Dose)

Drug

Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation.

Other names: Normal saline administered pre-extubation

Normal Saline (Placebo)

Other

Participants receive an equivalent volume of normal saline 10 minutes before extubation.

Primary outcomes

  1. Changing Preoperative Anxiety Score (STAI)

    Time frame: 15 minutes (T1-T2)

    Comparison of the State-Trait Anxiety Inventory (STAI) state anxiety score measured in the preoperative waiting room (T1) with the STAI score 15 minutes after the palming technique (T2). The difference between the two time points is analyzed to assess the anxiety-reducing effect of the intervention.

Secondary outcomes

  1. Hemodynamic Parameter Changes

    Time frame: 15 minutes (T1-T2)

    Changes in heart rate (HR) values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.

  2. Hemodynamic Parameter Changes

    Time frame: 15 minutes (T1-T2)

    Changes in mean blood pressure values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.

Sponsors and collaborators

Lead sponsor

Yuzuncu Yil University

Other

Registry information

Official study title

Effect of Subanesthetic Dose Propofol Use Before Extubation on Recovery From Anesthesia, Agitation on Recovery, and Patient Satisfaction

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Dec 11, 2025
Registry last updated
Dec 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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