Skip to main content
OpenTrials
Completed

NCT Number: NCT02914119

Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals

Aim: To explore

* the frequency of use of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia * the incidence of residual neuromuscular blockade, and * the timing of reversal of the neuromuscular blockade at the end of anaesthesia.

We will collect data from 7 Danish anaesthesia departments, using data from the Anaesthesia Information Management System (AIMS).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Neuromuscular Blockade

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Herlev Hospital

Herlev, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who received general anaesthesia with neuromuscular blockade in one of the 7 hospitals providing data for the study in the last 18 months up until the time of data collection

Treatment and study plan

Rocuronium

Drug

Succinylcholine

Drug

Cisatracurium

Drug

Mivacurium

Drug

Objective neuromuscular monitoring (acceleromyography)

Device

Sugammadex

Drug

Neostigmine

Drug

Primary outcomes

  1. Number of Participants With and Without Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Non-depolarizing Neuromuscular Blocking Agent (NMBA) (Yes/no)

    Time frame: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

  2. Number of Participants With and Without Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Depolarizing NMBA (Succinylcholine) (Yes/no)

    Time frame: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

Secondary outcomes

  1. Last Recorded Train-of-four (TOF) Ratio Before Tracheal Extubation or Removal of Supraglottic Airway Device in Patients Receiving a Non-depolarizing NMBA

    Time frame: in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

    The train-of-four (TOF) ratio is the ratio between the last and first measurements after four stimuli of the ulnar nerve at 2 Hz. The ratio should be at least 0.9 before tracheal extubation.

  2. Number of Participants With and Without Administration of Sugammadex in Cases Receiving a Non-depolarizing NMBA (Yes/no)

    Time frame: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

  3. Number of Participants With and Without Administration of Neostigmine in Cases Receiving a Non-depolarizing NMBA (Yes/no)

    Time frame: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

  4. Time in Minutes From Tracheal Extubation or Removal of Supraglottic Airway Device to Discharge From Post-anaesthesia Care Unit in Cases Involving a Non-depolarizing NMBA With and Without Neuromuscular Monitoring, Respectively

    Time frame: in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 180 minutes

  5. Number of Participants With and Without Mild Oxygen Desaturation (<90%, But >80%) in Cases Receiving a Non-depolarizing NMBA

    Time frame: in the period between tracheal extubation or removal of supraglottic airway device and discharge from post-anaesthesia care unit, assessed up to 24 hours

  6. Number of Participants With and Without Severe Oxygen Desaturation (<80%) in Cases Receiving a Non-depolarizing NMBA

    Time frame: in the period between tracheal extubation or removal of supraglottic airway device and discharge from post-anaesthesia care unit, assessed up to 24 hours

Sponsors and collaborators

Lead sponsor

Jakob Louis Thomsen

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Official study title

Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals - a Cross-sectional Study

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Sep 26, 2016
Registry last updated
Sep 12, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.