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OpenTrials
Completed

NCT Number: NCT02858115

Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation

During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation. The investigators hypothesized that the assessment by transesophageal echocardiography (TEE) of subaortic velocity time index (VTI) variation after 100 ml of crystalloid would predict fluid responsiveness in patients receiving one-lung ventilation.

This retrospective, observational, single center study was from January 2014 to December 2015. The investigators included 105 patients requiring one lung ventilation lung resection. The investigators analysed 39 patients presenting an acute circulatory failure. 100 ml of crystalloid was infused over 1-min. After an echocardiographic assessment at 1-min, remaining 400 ml were administered over 14-min Fluid responsiveness was defined as an increase in the VTI above 15% after infusion of 500 ml of crystalloid.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

hôpital Nord Assistance Publique Hôpitaux de Marseille

Marseille, 13015, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Lung resection
  • Acute circulatory failure
  • One-lung ventilation

Exclusion criteria

  • Sinusal rhythm

Treatment and study plan

Fluid challenge

Other

100 ml of crystalloid was infused over 1-min

Trans-oesophageal echography

Other

an echocardiographic assessment at 1-min,

Primary outcomes

  1. Fluid responsiveness

    Time frame: one day

    increase of cardiac output of more than 15%

  2. Velocity time index

    Time frame: one day

    : Echographic assesment of cardiac output

Secondary outcomes

  1. Pulsed pressure variation

    Time frame: one day

    dynamic indice of fluid responsiveness

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
Aug 8, 2016
Registry last updated
Aug 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.