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Completed

NCT Number: NCT01238718

Use of Lidocaine in Rapid Sequence Induction

Lidocaine has been shown to blunt the cardiovascular response to endotracheal intubation. The incidence of hypertension, tachycardia and dysrhythmias due to laryngoscopy may be increased in patients that receive rapid sequence induction and intubation, where opioids are spared and intravenous anesthetic agents are not titrated step by step. Our hypothesis was that lidocaine when administered intravenously in patients who undergo rapid sequence induction may not only blunt the hemodynamic response to intubation, but may also increase the anesthetic depth (as assessed by BIS), thus further reducing the possibility of hypertension, arrhythmias and also awareness.

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Key information

Conditions

Hemodynamic Response

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Aretaieio Hospital, University of Athens

Athens, Attica, 11528, Greece

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • reason for rapid sequence induction (emergency, reflux),
  • ASA I-II,
  • no antihypertensive drugs,
  • no antiarrhythmic drugs

Exclusion criteria

Treatment and study plan

Lidocaine

Drug

lidocaine 1.5 mg/kg intravenously

Placebo

Drug

normal saline

Primary outcomes

  1. BIS changes after lidocaine administration in rapid sequence induction

    Time frame: change from baseline in BIS values during 10 minutes

Secondary outcomes

  1. change in blood pressure

    Time frame: change from baseline in blood pressure during 10 minutes

  2. change in Heart rate

    Time frame: change from baseline in heart rate durng 10 minutes

Sponsors and collaborators

Lead sponsor

University of Athens

Other

Registry information

Official study title

Impact of Lidocaine on Anesthetic Depth During Rapid Sequence Induction

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Nov 11, 2010
Registry last updated
Aug 24, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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