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Completed

NCT Number: NCT02826369

Use of Compressed Sensing in Breast MRI

Breast MRI is increasingly important in breast screening imaging. It is currently based on dynamic sequences after contrast injection whose temporal resolution must be less than 90 seconds with dynamic acquisitions at different times.

These curves profiles are designed to differentiate benign from malignant lesions. Recently, Mann et al, (2014) showed that increasing the temporal resolution of dynamic acquisitions; lesion enhancement curves over time were more accurate than the curves usually performed.

It seems necessary to work on sequences having better temporal resolution without compromising however spatial resolution.

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Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

Up to 18 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Institut de Cancérologie de Lorraine

Vandœuvre-lès-Nancy, 54500, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient to benefit a MRI in the assessment for a breast carcinoma
  • Age >18 years old
  • Assessment on 3.0 Tesla in Magnetic Resonance Imaging
  • ECOG performance status ≤ 3
  • Ability to provide an informed written consent form

Exclusion criteria

  • Age < 18 years old
  • Claustrophobia
  • Contraindication to the injection of gadolinium contrast medium
  • Contraindication to MRI
  • Persons deprived of liberty or under supervision

Treatment and study plan

3.0 Tesla in Magnetic Resonance Imaging

Other

Eligible patient will have a standard MRI. The images taken before 4min30 and after 6min after to the injection of gadolimium contrast medium will be carried out with the standard image acquisition.

The images taken between 4min30 and 6min after the injection of gadolimium contrast medium will be carried out with the compressed sensing image acquisition.

Primary outcomes

  1. Agreement between compressed sensing and standard image acquisition

    Time frame: 1 day

    Agreement between compressed sensing and standard image acquisition is defined by percentage of lesions detected by both modes of acquisitions

Secondary outcomes

  1. Analysis of dammage contours

    Time frame: 1 day

    Analysis of lesions contours will be performed according to Bi-RADS classification

  2. Image quality in compressed sensing acquisition

    Time frame: 1 day

    The image quality will be evaluated using a quality scale

Sponsors and collaborators

Lead sponsor

Institut de Cancérologie de Lorraine

Other

Registry information

Acronym: COMPRIM

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jul 11, 2016
Registry last updated
Aug 8, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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