Use of Anti-CD146 Autoantibodies for the Diagnosis of Pulmonary Diseases Secondary to Occupational Exposure to Silica

Inclusion criteria

for non-exposed group:

• Subject, male or female, aged 18 or over
• Subject with low exposure to silica <0.1 mg/m3 in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix
• Subjects capable of consenting to participate in the study by signing a written informed consent form
• Subjects who are beneficiaries of or affiliated with a social security system

Inclusion criteria

for exposed group:

• Subject, male or female, aged 18 or over
• Subject with moderate or high exposure to silica (>= 0.1 mg/m3) in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix.
• Subjects capable of consenting to participate in the study by signing a written informed consent form
• Subjects who are beneficiaries of or affiliated with a social security system

Exclusion criteria

for each group:

• Minor subject
• Subject refusing to undergo the examinations required by the protocol
• Contraindications to respiratory function tests: Recent eye or throat surgery, recent myocardial infarction or pulmonary embolism, poorly controlled high blood pressure, recent pneumothorax.
• Pregnant or breastfeeding women, patients under guardianship or curatorship, deprived of liberty