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Completed

NCT Number: NCT05817357

Use of Air Purifiers to Improve Respiratory Health in Children

The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

* Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes * Is the use of an air purifier in the home acceptable to children and young people and their families?

Children and young people with asthma attending our clinic will be selected at random to be invited to take part. For those that take part, an air purifier (Rensair Ltd. - Rensair Compact) will be installed in their home for a one-year period. Data will be collected on numbers of asthma attacks, rescue oral steroids, quality of life, symptoms, lung function at the beginning and at three-monthly intervals throughout the study period. The acceptability to children and young people and their families taking part in this study of using an air purifier in their home will also be assessed.

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Key information

Conditions

Asthma in Children

Age range

5 year–15 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Alder Hey Children's Hospital

Liverpool, Merseyside, L12 2AP, United Kingdom

About this study

The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

  • Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes (including reduction in asthma exacerbations, improvement in symptom control, improvement in quality of life).
  • Is the use of an air purifier in the home acceptable to children and young people and their families?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 5 to 15 years old
  • Attend the asthma clinic in our hospital
  • Have a confirmed physician-diagnosis of asthma from the asthma clinic
  • Live in mainland England (this is due to delivery of the air purification units and also associated maintenance of them)

Exclusion criteria

  • Nil specific other than not meeting inclusion criteria

Treatment and study plan

Rensair Compact air purifier unit

Device

Installation of Rensair Compact air purifier (Rensair Ltd.) in the homes of children/young people participating in this study

Primary outcomes

  1. Number of asthma exacerbations (asthma attacks)

    Time frame: 12 months

    Asthma attacks and unscheduled healthcare visits due to acute asthma (including ED attendance, admission, GP/primary care attendance) - assessed by questionnaire and hospital-recorded attendances/admissions

  2. Number of rescue oral steroid courses

    Time frame: 12 months

    Number of rescue oral steroid courses - assessed by questionnaire and prescription data

  3. Quality of life - mini paediatric asthma quality of life questionnaire score

    Time frame: 12 months

    Quality of life using mini paediatric asthma quality of life questionnaire - the higher the score the better the quality of life

  4. Asthma control test score

    Time frame: 12 months

    Asthma control test (ACT) or child asthma control test score (cACT) - depending on age of participant - the higher the score the better the asthma control

  5. Amount of asthma reliever medication use per week

    Time frame: 12 months

    Amount of use of asthma reliever medication use over a one week period (assessed as a categorical value)

  6. Number of school days absent due to asthma

    Time frame: 12 months

    Number of school days missed due to asthma - assessed by questionnaire

  7. Number of parent/carer work days missed due to their child's asthma

    Time frame: 12 months

    Number of work days missed due to child's asthma - assessed by questionnaire

  8. Forced expired volume in one second (FEV1)

    Time frame: 12 months

    Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  9. Forced vital capacity (FVC)

    Time frame: 12 months

    Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  10. FEV1:FVC

    Time frame: 12 months

    Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  11. Measurement of fraction of exhaled nitric oxide (FeNO)

    Time frame: 12 months

    Fraction of exhaled nitric oxide measurements

  12. Acceptability to children and families participating of using an air purifier in their home

    Time frame: 12 months

    Acceptability to children and young people and their families taking part in the study in terms of use of air purifier in their homes - assessed by questionnaire

Sponsors and collaborators

Lead sponsor

University of Liverpool

Other

Registry information

Official study title

Use of Air Purification Devices in the Homes of Children and Young People to Improve Respiratory Health - a Pilot Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Apr 18, 2023
Registry last updated
Dec 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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