King abd el Aziz specialist hospital
Ta'if, 21944, Saudi Arabia
Completed
NCT Number: NCT04403191
Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy
To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.
Completed
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Notify MeKey information
Age range
18 year–65 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
postoperative nausea and vomiting
Exclusion criteria
systemic disease as diabetes or hypertension local gastric diseases
Treatment and study plan
ondansetron
Drugondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group
isopropyl alcohol 70% inhalation
Druginhalation every 15 min for 4 times then repeated after 6 hours
laparoscopic appendectomy
Procedureall patients received post operatively after laparoscopic appenectomy
Primary outcomes
-
numbers of vomiting attacks
Time frame: for one day
numbers of vomiting attacks recorded every 15 minutes for one day
Sponsors and collaborators
Lead sponsor
King Abdul Aziz Specialist Hospital
Network
Registry information
Official study title
Comparative Study Between Ondansetron, Isopropyl Alcohol Inhalation and Super Hydration in Treatment of Postoperative Emesis After Laparoscopic Appendectomy
Important dates
- Study start
- 2019
- Primary completion
- 2020
- Study completion
- 2020
- First posted
- May 27, 2020
- Registry last updated
- May 28, 2020
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.