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OpenTrials
Completed

NCT Number: NCT03692104

US-CT Fusion for Post Implant Dosimetry

Post implant dosimetry is an essential part of quality assurance after permanent seed prostate brachytherapy. CT imaging is the standard of assessment but due to contouring uncertainties, MR-CT fusion is preferred. This is not always available due to financial restrictions. This study explores the possibility of post implant US-CT fusion to improve contouring accuracy and potentially replace the use of MR-CT fusion.

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Key information

Conditions

Prostate Cancer Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

40 year–80 year

Sex eligibility

Male

Study type

Observational

Primary location

BC Cancer

Kelowna, British Columbia, V1Y5L3, Canada

About this study

25 participants undergoing permanent seed prostate brachytherapy will be approached to undergo collection of prostate US images at the completion of their procedure. This will add approximately 5 minutes to the duration of their brachytherapy procedure. The US study will not entail any discomfort or risk to participants as they are still under anesthesia for the implant procedure. The institution standard of care for quality assurance will be complied with, obtaining a CT and MRI of the prostate at 30 days after the procedure. These will be co-registered and analyzed in the normal fashion. In addition, the post implant US images will also be co-registered with the CT and the resulting dosimetric parameters compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • localized prostate cancer suitable for permanent seed implant brachytherapy as either monotherapy or as a boost

Exclusion criteria

  • Unable to undergo MRI

Treatment and study plan

transrectal ultrasound

Diagnostic Test

Use of US for post implant quality assessment

Primary outcomes

  1. Comparison of prostate dosimetry assessed by US-CT fusion with respect to the standard MR-CT fusion

    Time frame: 1 month

    Dosimetry will be calculated using 2 different imaging modalities (US vs MRI) and compared

Secondary outcomes

  1. Comparison of prostate volume assessed by 2 different imaging modalities

    Time frame: 1 month

    Assessment of prostate volume as contoured on US vs MRI post implant

Sponsors and collaborators

Lead sponsor

British Columbia Cancer Agency

Other

Registry information

Official study title

Comparison Between Postoperative Ultrasound-CT Fusion With MRI-CT Fusion for Postimplant Dosimetry for Prostate LDR Permanent Seed Brachytherapy

Important dates

Study start
2017
Primary completion
2018
Study completion
2019
First posted
Oct 2, 2018
Registry last updated
Jan 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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