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OpenTrials
Completed

NCT Number: NCT03447002

Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

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Key information

Conditions

Premature Ventricular Contraction Arrhythmias, Cardiac Cardiac Complexes, Premature Cardiac Conduction System Disease Cardiovascular Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Obstetric Labor Complications Obstetric Labor, Premature Pathologic Processes Pathological Conditions, Signs and Symptoms Pregnancy Complications Premature Birth Urogenital Diseases Ventricular Premature Complexes

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Erciyes university Yilmaz- mehmet öztaşkın heart hospital

Kayseri, Turkey (Türkiye)

About this study

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • PVC's rate is more than % 5 in 24 hours rhythm recording

Exclusion criteria

  • ischemic heart disease
  • hyperthyroidism
  • patients with low ejection fraction

Treatment and study plan

24 hours urine levels metanephrine and normetanephrine

Diagnostic Test

24 hours rhythm recording and 24 hours urine measurement

Other names: rhythm recording

Primary outcomes

  1. metanephrine and normetanephrine levels

    Time frame: about 10 months

    metanephrine and normetanephrine levels asociated premature ventricular complex frequents

Sponsors and collaborators

Lead sponsor

TC Erciyes University

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Feb 27, 2018
Registry last updated
Nov 14, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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