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OpenTrials
Completed

NCT Number: NCT02813109

Urine Biomarkers for Renal Function Monitoring in Preterm Infants

The true renal function of preterm infants is difficult to evaluate. Serum creatinine (Cr) levels in infants are unreliable as a detector of renal function in the first few days of life because they may continue to reflect maternal levels. Although few candidates appear to be a useful biomarker for kidney injury, scant reference data on these biomarker in preterm infants exist, and studies have yielded conflicting results. Therefore, we aimed to determine the reliable urinary biomarkers to detect kidney injuries in preterm infants.

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Key information

Conditions

Premature Infant Female Urogenital Diseases and Pregnancy Complications Obstetric Labor Complications Obstetric Labor, Premature Pregnancy Complications Premature Birth Urogenital Diseases

Age range

1 day–2 week

Sex eligibility

All sexes

Study type

Observational

Primary location

Inha University Hospital, Incheon, South Korea

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • premature infants born before 37 weeks of gestational age

Exclusion criteria

  • cardiac or renal anomalies
  • transferred in 2 days after birth from other hospitals

Treatment and study plan

Primary outcomes

  1. correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine

    Time frame: postnatal 1day

  2. correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine

    Time frame: postnatal 3day

  3. correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine

    Time frame: postnatal 5day

  4. correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine

    Time frame: postnatal 7day

Sponsors and collaborators

Lead sponsor

Inha University Hospital

Other

Collaborators

  • Hallym University Medical Center

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jun 24, 2016
Registry last updated
Apr 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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