Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

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Key information

Conditions

Renal Insufficiency, Chronic Cardiovascular Diseases Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hypertension Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Medicine, Holstebro Hospital

Holstebro, Ringkjoebing, 7500, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
Creatinine clearance between 30-59 ml/min
Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
Healthy volunteers, aged between 18 and 65, both men and women

Exclusion criteria

Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
Cancer
Alcohol abuse
Medicine abuse
Pregnancy

Sponsors and collaborators

Lead sponsor

Erling Bjerregaard Pedersen

Other

Registry information

Official study title

Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

Important dates

Study start: 2004
Primary completion: 2008
First posted: Apr 12, 2006
Registry last updated: Aug 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed