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Completed

NCT Number: NCT00568724

Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis

The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.

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Key information

Conditions

Ureteral Obstruction Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hydronephrosis Kidney Diseases Male Urogenital Diseases Ureteral Diseases Urogenital Diseases Urologic Diseases

Age range

3 month–15 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Clinical Medicine, University of Aarhus

Aarhus, 8200, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction.
  • Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.

Exclusion criteria

  • Bilateral hydronephrosis
  • Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs.
  • Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections < 6 months.
  • Neurogenic bladder dysfunction.
  • GFR < 40 % standardized to age.
  • Non-compliance. Linguistic difficulties.

Treatment and study plan

Primary outcomes

  1. Urinary cytokines

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Aarhus University Hospital

Registry information

Important dates

Study start
2007
Primary completion
2012
Study completion
2012
First posted
Dec 6, 2007
Registry last updated
Sep 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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