Uric Acid Levels and Endothelial Functions

Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined. The aim of this study was to determine the relationship of serum uric acid, inflammatory markers and CED.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Inflammation Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

50 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Referred to Mayo Clinic for cardiac catheterization
Postmenopausal

Exclusion criteria

History of percutaneous coronary intervention
Coronary artery bypass graft surgery
Unstable angina pectoris
Valvular heart disease
Peripheral vascular disease
Known congestive heart failure

Treatment and study plan

Questionnaire of overall health

Other

The standardized questionnaire was used to assess occurrence of major adverse cardiovascular events including stroke, re-hospitalization, myocardial infarction or death. Responses were verified by medical record review conducted by an investigator blinded to the results of the standardized questionnaire.

Primary outcomes

Serum Uric Acid Level

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)

Registry information

Official study title

Clinical Follow-up of Patients With Assessment of Endothelial Dysfunction/Coronary Spasm

Important dates

Study start: 1992
Primary completion: 2016
Study completion: 2016
First posted: Aug 11, 2016
Registry last updated: Aug 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed