Urethral Vascularization and Urodynamics

The urethra plays a crucial role in maintaining urinary continence. Its complex blood supply is still not well understood. Particularly in the context of urethral pressure. Urethral pressure can be measured by bladder and urethral pressure studies (urodynamic).

This study aims to use advanced imaging techniques to analyse the blood supply of the urethra and correlate it to urethral pressure measurements.

Elucidating these relationships will improve our understanding of urethral function and malfunction, and ultimately optimise diagnosis and treatment of stress urinary incontinence. A total of 35 participants with stress urinary incontinence and 35 without stress urinary incontinence will be asked to participate in this study.

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Key information

Conditions

Stress Urinary Incontinence Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Lower Urinary Tract Symptoms Male Urogenital Diseases Metaplasia Neovascularization, Pathologic Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Ultrasound Urinary Incontinence Urinary Incontinence, Stress Urination Disorders Urodynamic Exam Urogenital Diseases Urologic Diseases Urological Manifestations Vascularisation

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Bern, Inselspital

Bern, Canton of Bern, 3013, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Urodynamic examination
Written informed consent
Understanding of the German language
Indicated urodynamic assessment
Endovaginal and perineal ultrasound feasible

Exclusion criteria

Urinary tract infections
Transgender Population
Pregnancy
History of incontinence or prolapse surgery
Pelvic prolapse higher than second degree
Prior pelvic radiotherapy
Prior history of gynecologic tumor

Treatment and study plan

3D ultrasound

Diagnostic Test

Virtual Organ Computer-aided AnaLysis (VOCAL) to assess flow and velocity characteristics of the urethral blood supply

Primary outcomes

Color histogram index (Vascularity Index)

Time frame: Enrollment by the urodynamic examination until the ultrasound measurement (VOCAL) up to 4 weeks

Doppler Indices (Vascularity Index) generated by Virtual Organ Computer-aided AnaLysis (VOCAL)

Sponsors and collaborators

Lead sponsor

Insel Gruppe AG, University Hospital Bern

Other

Registry information

Official study title

UVASC Urethral Vascularization and Urodynamics

Acronym: UVASC

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Sep 22, 2025
Registry last updated: May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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