Upper Gastrointestinal Perforations: a Nationwide Registry-based Study

The primary aim of this project is to increase the knowledge about how perforations in the esophagus, stomach and small intestine are treated on a national level. Furthermore, secondary aims include assessment of how different treatment options and type of treating facilities relate to patient survival. This will be done by studying information about all adult patients with an upper GI perforation treated in Sweden during 2005-2023.

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Key information

Conditions

Acute Abdomen Abdomen, Acute Abdominal Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska University Hospital

Stockholm, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age of at least 18 years
perforation in either oesophagus, stomach or small intestine
treatment carried out in Sweden
diagnosis set between January 2005 and August 2023

Exclusion criteria

children

Treatment and study plan

Surgical treatment type

Procedure

This observational design will study the clinical outcome for each type of upper gastrointestinal perforation in relation to surgical or non-surgery treatment and in relation to treatment centre.

Primary outcomes

Mortality

Time frame: One year after diagnosis

Mortality up to one year after diagnosis

Study contacts

Contact information is provided by the study sponsor or research team.

Rebecka Ahl Hulme, MD, PhD

CONTACT

[email protected]

0046812373212

Sponsors and collaborators

Lead sponsor

Region Stockholm

Other Gov

Registry information

Official study title

Risk Factors for and Survival After Oesophageal, Gastric and Small Intestinal Perforations: a National Observational Registry-based Cohort Study

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 4, 2023
Registry last updated: Dec 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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