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Completed

NCT Number: NCT06147726

Upper Extremity Rehabilitation With Virtual Reality in Parkinson's Disease Patients

Upper extremities are the first part of the body to be affected by Parkinson's disease. Although studies have shown that virtual reality-assisted rehabilitation methods are effective on gait and balance, studies on their use for upper extremity rehabilitation are limited. For this reason, the aim of the project is to examine whether virtual reality supported upper extremity position matching exercises, which will be specially prepared according to joint ranges of motion, will provide functional improvement in the upper extremities of individuals with Parkinson's disease.

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Key information

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Health Sciences Bolu Abant Izzet Baysal University

Bolu, Merkez, 14100, Turkey (Türkiye)

About this study

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor disorders. Difficulties in using the upper limbs caused by these motor impairments are common with the disease. Upper limb motor impairments in PD include slowness of movement, difficulties in performing sequential tasks and limitations in upper limb function. Studies show that the upper extremities are usually the most affected body region in the early stages of PD. Despite this, the number of rehabilitation methods that can be used for upper extremity rehabilitation is limited. Impairments in upper extremity motor function constitute a leading problem in the lives of individuals with PD by affecting their ability to perform activities of daily living. Virtual reality applications stand out as an innovative approach in neurorehabilitation. Previous studies have reported positive effects of virtual reality on gait function and balance in PD. However, the number of studies designed with virtual reality for the upper limb is limited. Therefore, this project aims to fill the gap in the literature by examining the effectiveness of virtual reality-based rehabilitation in PD with a particular focus on upper extremity motor function and proprioception.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Accepting to participate in the research
  • Being diagnosed with Parkinson's Disease by a neurologist
  • Continuing anti-parkinsonian medication
  • Hoehn-Yahr (H-Y) stage 3 and below
  • Ability to walk independently
  • To have full range of motion in shoulder abduction and elbow extension movements

Exclusion criteria

  • Presence of additional neurological diseases other than Parkinson's Disease
  • Scores below 21 on the Montreal Cognitive Assessment Scale
  • Change in medication dosage in the last 1 month
  • Severe visual impairment or complete hearing impairment in both ears
  • Having a rheumatologic, musculoskeletal, etc. disease that may affect upper extremity functions
  • The occurrence of severe tremors or dyskinesias due to the end of the drug dose
  • Failing the Titmus butterfly test

Treatment and study plan

Upper extremity position matching exercises in virtual reality

Other

In addition to conventional treatment approaches for 20 minutes 2 days a week for 8 weeks, joint positioning exercises (4 different game sequences of 4 minutes, 1 minute rest between each sequence, total 20 minutes) designed specifically for the individual's existing range of motion will be applied to the VR group.

Conventional Physiotherapy

Other

proprioceptive neuromuscular facilitation techniques, parkinson-specific upper extremity and balance and gait exercises

Primary outcomes

  1. Box and Block Test (BBT)

    Time frame: through study completion, an average of 1 year

    The Box and Block Test (BBT) is widely used in neurological rehabilitation to assess upper extremity motor function, gross manual dexterity, and coordination. The test apparatus consists of a partitioned box measuring 53.7 × 25.4 × 8.5 cm and 150 wooden cubes.

    During administration, the box is placed in front of the participant with the partition aligned to the midline. The participant is instructed to transfer the cubes from one compartment to the other using the test hand as quickly as possible. At the end of the trial, the therapist records the score by counting the number of cubes successfully transferred.

  2. Proprioception Assessment

    Time frame: through study completion, an average of 1 year

    Position, i.e. proprioceptive sensation, will be evaluated with the "angle repetition test", one of the methods commonly used in the clinic. The person will be positioned in a sitting position with his/her back unsupported and feet touching the floor. The angle repetition test will be performed with a mobile device fixed above the elbow and between the shoulder. The person's eyes will be closed during the assessment to prevent the learning effect and the use of visual reference. After the shoulder is brought to the reference angle, the person is allowed to perceive the angle by waiting 10 seconds. The person will then be asked to bring his/her shoulder to the side of his/her body and then repeat the taught reference angle as he/she perceived it. The absolute value of the angle deviated from the target will be recorded. Measurements in the shoulder joint will be made at 40° and 100° angles.

Secondary outcomes

  1. Unified Parkinson's Disease Rating Scale

    Time frame: through study completion, an average of 1 year

    It is the most frequently used, valid and reliable scale for the assessment of impairments and disabilities in PD. It contains 42 items, consists of 4 sections and assesses patients' mental status, behavior and mental state (4 items), activities of daily living (13 items), motor functions (14 items) and treatment complications (11 items), respectively. Mental status; 16 points, activities of daily living; 52 points, motor functions; 108 points and treatment complications; 23 points, totaling 199 points. Higher scores indicate worsening of the patient's condition. An 8-point change in the total score was found to determine minimal clinically significant change.

  2. Disabilities of the Arm, Shoulder, and Hand Questionnaire

    Time frame: through study completion, an average of 1 year

    It is a questionnaire consisting of a total of 30 questions used to evaluate the ability of the patient with upper extremity problems in activities of daily living and upper extremity functions. The first 21 questions ask about the degree of difficulty in performing various activities of daily living with the dominant limb in the last week, the next 5 questions ask about the degree of pain, numbness, weakness during activities and the last 4 questions ask about the effect of pathologies on sleep, work, social life and psychological status. For each question, the patient marked the appropriate response on a 5-point Likert-type scale. 1 indicates no difficulty, 2 indicates mild difficulty, 3 indicates moderate difficulty, 4 indicates extreme difficulty, and 5 indicates no difficulty at all. The questionnaire is evaluated between 30 and 150 points.

  3. Parkinson's Disease Questionnaire (PDQ-8)

    Time frame: through study completion, an average of 1 year

    The questions in the PDQ-8 assess the condition of the individual in the last 1 month and are scored between 0 (never) and 4 (always). The total score is converted to a 100-point system and a high score indicates a decrease in quality of life.

  4. Intrinsic Motivation Inventory (IMI)

    Time frame: average 1 year after the completion of the study

    The Intrinsic Motivation Inventory (IMI) is used to assess motivation and satisfaction during task performance. It is a multidimensional questionnaire that evaluates interest/enjoyment, perceived competence, pressure/tension, perceived choice, and value/usefulness. Responses are rated on a Likert scale ranging from "not at all true" to "very true." The total motivation score is calculated by summing the item scores.

Sponsors and collaborators

Lead sponsor

Ramazan KURUL

Other

Collaborators

  • Abant Izzet Baysal University

Registry information

Official study title

Effectiveness of Virtual Reality Supported Upper Extremity Position Matching Exercises in Parkinson's Disease Patients

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 28, 2023
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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