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NCT Number: NCT06976528

Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults

Emerging Adults (EA) engage in heavy episodic drinking (HED) at a greater quantity and frequency than any other time in their lives, which may lead to significant short- and long-term consequences. Although much is known about the influence of peers in EA alcohol use, there is a dearth of research examining the ways in which romantic partners influence EA drinking behaviors. The proposed study bridges a crucial gap in the existing literature by examining behavioral and physiological risk and resilience factors in the acute link between EA relationship conflict and alcohol consumption. EA couples will engage in two conflict resolution tasks interspersed with two puzzle tasks and two alcohol administration procedures. Because high frequency heart rate variability (HF-HRV) is associated with alcohol use and emotion regulation during stressful experiences, HF-HRV and other physiological data will be collected throughout the laboratory procedures.

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Key information

Age range

21 year–29 year

Sex eligibility

All sexes

Study type

Observational

Primary location

386 Park Avenue South

New York, 10016, United States

Location status: Recruiting

Location contact

Sarah Harris

CONTACT

[email protected]

914-419-4745

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 21-29 years old
  • Must be in a committed romantic relationship of at least 3 months duration
  • Must report at least 2 HED episodes in the past 30 days (5 or more drinks within 2 hours for males, 4 or more drinks within 2 hours for females)
  • Must self-report that they have - on at least three occasions during the past year - consumed a quantity of alcohol that is equal to or greater than the standard dose administered for their weight in the laboratory

Exclusion criteria

  • Meeting DSM-5 criteria for a history of or current neurological, psychotic, or bipolar disorders
  • History of self-reported head trauma requiring medical treatment
  • Body weight exceeding 250 pounds
  • Current enrollment in treatment or seeking treatment for a substance or alcohol use disorder
  • Current suicidal or homicidal intent
  • Serious cardiovascular health conditions (e.g. pacemaker, cardiac arrhythmia, hypertension) that may alter normative cardiac functioning
  • Treatment on medications such as lithium, methadone, alpha or beta blockers or cholinergic/anticholinergic medications likely to confound normative cardiovascular responding or response to alcohol administration. Stimulant or benzodiazepine medication use is permissible provided participants do not take medication on the day of study participation
  • Severe and/or unilateral physical IPV with your current partner at any time
  • Sexual IPV with current partner at any time
  • Fear of current partner
  • Pregnancy or breastfeeding
  • Severe Alcohol Use Disorder (as defined by the DSM-5)
  • Current diagnosis of anorexia or bulimia

Treatment and study plan

Primary outcomes

  1. Alcohol consumption

    Time frame: ~20 minutes

    Amount of alcohol consumed during the study

Secondary outcomes

  1. High frequency heart rate variability (HF-HRV)

    Time frame: ~3 hours

    High frequency heart rate variability (HF-HRV) is a neurally-derived measure of parasympathetic activity that may partially explain the association between stressful relationship conflict and alcohol misuse. HF-HRV is a measure of the variability in interbeat intervals, or the time in between beats of the heart.

Sponsors and collaborators

Lead sponsor

New York University

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
May 16, 2025
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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