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NCT Number: NCT04861051

Understanding Ketamine's Dissociative Effects (KD Study)

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

Recruiting

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Stanford University School of Medicine

Palo Alto, California, 94305, United States

Location status: Recruiting

Location contact

Karl Deisseroth, MD, PhD

CONTACT

About this study

The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during dissociation in epilepsy patients with stereoEEG.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient in Stanford Epilepsy Monitoring Unit
  • Age >18 years old.

Exclusion criteria

  • Lifetime psychotic or bipolar disorder
  • Inability to speak, read or understand English
  • Pregnant or nursing females
  • Prior adverse ketamine response

Treatment and study plan

ketamine

Drug

Study participants will receive 0.5mg/kg of ketamine - one single infusion

Other names: Ketalar

Primary outcomes

  1. Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale)

    Time frame: up to 1 week

    The CADSS is an instrument for the measurement of dissociative symptoms. The CADSS comprises 23 subjective items and participant's responses are coded on a 5-point scale (0 = Not at all; 4 = Extreme). The higher the number on the CADSS, the more severe the symptoms.

Study contacts

Contact information is provided by the study sponsor or research team.

Arjay Cordero

CONTACT

[email protected]

650-580-9000

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Understanding Ketamine's Dissociative Effects in Epilepsy (KD Study)

Important dates

Study start
2021
Primary completion
2028
Study completion
2028
First posted
Apr 27, 2021
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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