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Recruiting

NCT Number: NCT04579588

Understanding Immunity to the Flu Vaccine in COVID-19 Patients

The purpose of this study is to measure immunity to the flu vaccine over time in patients who have had COVID-19 and may have other medical conditions including obesity, type 2 diabetes, chronic fatigue, or long-term COVID-19 symptoms. Adults and children (age 9 to 64) who had been diagnosed with COVID-19 as well as controls without COVID-19 will be invited to participate in this study.

Recruiting

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Key information

Conditions

Corona Virus Infection Coronaviridae Infections Coronavirus Infections Flu Vaccine Immunity Infections Influenza, Human Nidovirales Infections Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

9 year–64 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University

Palo Alto, California, 94304, United States

Location status: Recruiting

Location contact

SNP Center Inquiry

CONTACT

[email protected]

(650) 521-7237

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 9 through 64 years
  • Diagnosed with COVID-19 at least 2 months prior enrollment
  • Patients with or without obesity, diabetes, chronic fatigue and/or long term COVID-19 symptoms
  • Patients without COVID-19 diagnosis for controls

Exclusion criteria

  • Received the influenza vaccine less than 4 months ago
  • Pregnant or lactating
  • Patients with special risks attendant to venipuncture
  • Use of immunomodulatory medications that may impact vaccine immune response per clinician's judgment
  • Contraindication to the flu vaccine
  • Immunodeficiency or autoimmune disease that may impact vaccine immune responses per clinician's judgement

Treatment and study plan

Flu shot

Biological

All participants will receive a single shot of the flu vaccine

Primary outcomes

  1. Testing immunity to the flu vaccine over time

    Time frame: 1 week

  2. Testing immunity to the flu vaccine over time

    Time frame: 1 month

Study contacts

Contact information is provided by the study sponsor or research team.

SNP Center Inquiry

CONTACT

[email protected]

(650) 521-7237

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

Registry information

Important dates

Study start
2020
Primary completion
2028
Study completion
2028
First posted
Oct 8, 2020
Registry last updated
Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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