Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics

The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Calgary, Calgary, Alberta, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group 1 No clinically overt heart failure
Group 2 Known coronary artery disease
Group 3 Known heart failure with preserved ejection fraction
Group 4 Known heart failure with reduced ejection fraction
Group 5 Healthy age-matched controls

Exclusion criteria

Age <18 years
Known malignancy with expected survival <1 year
Pregnant or recent pregnancy <6 months
Recent event (<2 weeks since Acute Coronary Syndrome, Heart failure or other admission
Severe mitral or aortic stenosis

Treatment and study plan

Primary outcomes

Percent of patients meeting new diagnostic criteria for HFpEF

Time frame: Up to 5 years

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Acronym: Alberta HEART

Important dates

Study start: 2009
Primary completion: 2015
Study completion: 2022
First posted: Feb 3, 2014
Registry last updated: May 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed