Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault

Following sexual assault, many individuals will develop chronic problems including posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD). Intervention provided soon after assault can decrease the risk of developing chronic psychopathology and associated negative consequences. Interventions that address common underlying mechanisms of PTSD and alcohol use, such as fear and reward systems, have strong potential utility as efficacious and accessible interventions for clinicians treating patients recently exposed to sexual assault. This proposal is designed to test fear and reward as crucial processes underlying recovery following sexual assault and elucidate the most efficacious treatment targets. Employing experimental tasks (safety-signal learning paradigm and probabilistic reward task) to capture baseline underlying vulnerabilities in fear and reward systems respectively will allow for exploration of how these processes impact recovery. A randomized clinical trial (N = 180) will be conducted to test efficacy of intervention approaches that target PTSD or alcohol use compared to supportive telehealth. In addition, a phased study design will allow for exploration of efficacy of primary and secondary intervention approaches to test the questions of 1) whether it is more efficacious to target PTSD or alcohol use first; and 2) whether it is necessary to target both PTSD and alcohol use to facilitate recovery or if one is sufficient. This proposal is significant in exploring transdiagnostic mechanisms implicated in recovery following sexual assault, fear and reward, and using a novel design to compare efficacy, ordering, and necessity of two distinct intervention approaches.

Inclusion criteria

• Identifies as female.
• Between the age of 18 and 65.
• Reports a sexual assault in the last 4 weeks to 1 year.
• Current PTSD severity of 23+ on the PSS-I-5.
• Current heavy alcohol use (2+ heavy episodic drinking occasions [4+ drinks on one occasion] in past month).
• Access to the internet and a device with a webcam.

Exclusion criteria

• Current diagnosis of schizophrenia, delusional disorder, or organic mental disorder as defined by the DSM-5.
• Current diagnosis of bipolar disorder, depression with psychotic features, or depression severe enough to require immediate psychiatric treatment (i.e., serious suicide risk with intent and plan).
• Unwilling or unable to discontinue current trauma-focused psychotherapy or current substance use psychotherapy.
• Unstable dose of psychotropic medications in the prior 3 months.
• Ongoing intimate relationship with the perpetrator of most recent assault.
• Current diagnosis of a severe substance use disorder according to DSM-5, other than alcohol in the last month.
• No clear trauma memory.
• Current higher dose use of benzodiazepines (greater than the equivalent of 4 mg of lorazepam, 2 mg alprazolam, 1.5 mg clonazepam, or 20 mg of diazepam).