NCT Number: NCT03935230
Uncontrolled Donation After Circulatory Determination of Death (uDCDD)
World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.
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Notify MeKey information
Age range
18 year–65 year
Sex eligibility
All sexes
Study type
Observational
About this study
While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.
Exclusion criteria
- Patients with a status of no resuscitation
- Pediatric patients (<18 years old)
- Adults >65 years old
Treatment and study plan
Primary outcomes
-
Potential contribution of a uDCDD program on the number of additional donors.
Time frame: 1 year
Defined as (must meet all criteria):
- Age ≤70 years old
- Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury)
- Absence of surgical cause of cardiac arrest
- No sign of IV drug abuse
- No history of malignancies
Secondary outcomes
-
Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.
Time frame: 1 year
Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.
-
Number of tissus donors
Time frame: 1 year
Number of tissus donors
-
Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.
Time frame: 1 year
Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.
-
Areas of future research.
Time frame: 1 year
Areas of future research.
Sponsors and collaborators
Lead sponsor
Université de Sherbrooke
Other
Registry information
Official study title
Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?
Acronym: uDCDD
Important dates
- Study start
- 2016
- Primary completion
- 2016
- Study completion
- 2016
- First posted
- May 2, 2019
- Registry last updated
- May 2, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.