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NCT Number: NCT05620329

UNC Pleural Fluid Registry

Research with biospecimens such as blood, tissue, or body fluids can help researchers understand how the human body works. Researchers can make new tests to find diseases, understand how treatments work, or find new ways to treat a disease. The purpose of this study is to collect biospecimens for research from patients with known or suspected lung cancer. The information learned from the biospecimens may be used in future treatments. The purpose of this protocol is to create a pleural fluid registry for use in future studies.

Recruiting

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Key information

Conditions

Lung Cancer Breast Cancer Breast Diseases Breast Neoplasms Empyema Infections Inflammation Lung Diseases Lung Infection Lung Neoplasms Malignant Pleural Effusion Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Pleural Diseases Pleural Effusion Pleural Effusion, Malignant Pleural Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Skin Diseases Skin and Connective Tissue Diseases Suppuration Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UNC Lingeberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

Location status: Recruiting

Location contact

Carmmen Garcia

CONTACT

[email protected]

919-966-4432

Jason Akulian, MD

PRINCIPAL_INVESTIGATOR

Luz Cuaboy

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who are 18 years or older
  • Inpatients and outpatients
  • Diagnosed with pleural fluid, are referred for and undergo clinically indicated drainage who have clinical evidence of:
  • pulmonary infection (such as fever, leukocytosis, new or worsening infiltrate on chest x-ray, or clinical deterioration) with effusion
  • malignancy

Exclusion criteria

  • A subject will not be eligible for inclusion in this registry if, in the investigator's (or treating clinician's) opinion, the patient has any concurrent medical condition that may preclude their ability to undergo pleural fluid drainage safely.
  • Incarcerated individuals

Treatment and study plan

Primary outcomes

  1. Creation of a pleural fluid registry

    Time frame: 32 years

    Biological specimens and corresponding clinical data from subjects will be collected during standard of care procedures and medical record abstraction to support the creation of a pleural fluid registry.

Study contacts

Contact information is provided by the study sponsor or research team.

Carmmen Garcia

CONTACT

[email protected]

+1 954-336-7499

Luz Cuaboy

CONTACT

[email protected]

+1 954-336-7499

Sponsors and collaborators

Lead sponsor

UNC Lineberger Comprehensive Cancer Center

Other

Registry information

Official study title

University of North Carolina Pleural Fluid Registry

Important dates

Study start
2018
Primary completion
2050
Study completion
2050
First posted
Nov 17, 2022
Registry last updated
Oct 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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