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NCT Number: NCT06530901

Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia

Based on the preoperative ultrasound detection of various parametric indicators of the inferior vena cava cross-section, including the ratio of the inferior vena cava's long and short axes, cross-sectional area and circumference during two-dimensional and three-dimensional imaging, as well as the changes in respiratory variability of each parameter, we explored the predictive value of IVC ultrasound indicator parameters on hypotension after induction of general anesthesia in elderly patients undergoing elective non-cardiac surgery, screened the sensitive indicators, and calculated the cut-off values.

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Key information

Age range

65 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

the Affiliated Hospital of Yangzhou University, Yangzhou University

Yangzhou, Jiangsu, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elderly patients undergoing elective non-cardiac surgery under general anesthesia;
  • Age 65-85 years old;
  • Body mass index (BMI) 18-28 kg/m2;
  • American society of anesthesiologists (ASA) class I-III.

Exclusion criteria

  • Patient refusal or lack of cooperation;
  • Inability to communicate properly;
  • Severe sinus bradycardia, pacemaker implantation, atrioventricular block, and atrial fibrillation;
  • Presence of severe hepatic and renal function abnormalities;
  • Preoperative cardiac ultrasound suggesting LVEF <50%;
  • Tricuspid valve displacement <16 mm by preoperative cardiac ultrasound;
  • Chronic obstructive pulmonary disease;
  • Pulmonary hypertension;
  • Administration of drugs that inhibit the renin-angiotensin-aldosterone system;
  • Possibility of a difficult airway.

Treatment and study plan

Multidimensional ultrasound of the inferior vena cava

Diagnostic Test

Cross-sectional parameters of the inferior vena cava include two-dimensional longitudinal diameter, cross-sectional length and short diameter, circumference, and cross-sectional area, as well as cross-sectional length and short diameter, circumference, and cross-sectional area in three-dimensional imaging

Primary outcomes

  1. Changes in the level of Mean Arterial Pressure

    Time frame: Baseline (before induction), 10 min after induction

    The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

  2. Changes in the level of Systolic Blood Pressure

    Time frame: Baseline (before induction), 10 min after induction

    The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

  3. Multidimensional ultrasound of the inferior vena cava

    Time frame: Baseline (before induction)

    The outcome above should be measured at the time before induction

Secondary outcomes

  1. Changes in the level of Heart Rate

    Time frame: Baseline (before induction), 10 min after induction

    The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

  2. Changes in the level of Diastolic Blood Pressure

    Time frame: Baseline (before induction), 10 min after induction

    The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

Study contacts

Contact information is provided by the study sponsor or research team.

zhuan zhang, professor

CONTACT

[email protected]

+8615062791355

Sponsors and collaborators

Lead sponsor

Zhuan Zhang

Other

Registry information

Official study title

Multidimensional Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 31, 2024
Registry last updated
Aug 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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