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NCT Number: NCT07609147

Ultrasound Measurement of Skin-to-Epiglottis Distance for Prediction of Difficult Airway in Adult Patients

This prospective observational study aims to evaluate the predictive value of ultrasound-measured skin to epiglottis distance for difficult airway in adult patients undergoing elective or emergency procedures requiring airway management. The correlation between ultrasound measurements and standard airway assessment parameters will be analyzed.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hacettepe Univercity

Ankara, Altındağ, 06320, Turkey (Türkiye)

About this study

Airway management is a critical component of anesthesia and intensive care practice. Predicting difficult airway remains challenging with conventional bedside tests. Ultrasound has emerged as a non-invasive, bedside tool for airway assessment. This study aims to investigate the relationship between skin-to-epiglottis distance measured by ultrasound and difficult laryngoscopy/intubation. Secondary comparisons will include traditional airway assessment methods such as Mallampati score, thyromental distance, and neck circumference

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥18 yaş elective surgery

Exclusion criteria

  • emergency surgery
  • head and neck surgery
  • pregnant patients

Treatment and study plan

Primary outcomes

  1. Skin to epiglottis distance

    Time frame: Preintubation (within 30 minutes before procedure)

    Distance measured via ultrasound in the anterior neck region

Secondary outcomes

  1. Incidence of difficult laryngoscopy (Cormack-Lehane grade ≥ 3)

    Time frame: During intubation procedure (intraoperative period)

    The proportion of patients with difficult laryngoscopy defined as Cormack-Lehane grade 3 or 4 during direct laryngoscopy.

  2. Intubation Difficulty Score (IDS)

    Time frame: During intubation procedure

    Assessment of intubation difficulty using the Intubation Difficulty Score based on number of attempts, operators, alternative techniques, glottic exposure, lifting force, external laryngeal pressure, and vocal cord position.

  3. Correlation between ultrasound measurements and Mallampati score

    Time frame: Preoperative assessment

    Correlation between tracheal diameter and skin to epiglottis distance measured by ultrasound and preoperative Mallampati classification.

  4. Skin-to-Epiglottis Distance Measured by Ultrasound

    Time frame: Immediately before induction of anesthesia

    Skin-to-epiglottis distance will be measured using ultrasound immediately before anesthesia induction. The distance is recorded in millimeters (mm) as a continuous variable. Larger values indicate a greater skin-to-epiglottis distance and may be associated with an increased likelihood of difficult laryngoscopy. This is not a scored scale; therefore, no predefined minimum or maximum score exists.Cormack-Lehane Grading System. Scores range from Grade I to Grade IV. Grade I indicates full visualization of the glottis (easier laryngoscopy), whereas Grade IV indicates that neither the glottis nor the epiglottis is visible (most difficult laryngoscopy). Higher grades indicate a worse airway view.

Study contacts

Contact information is provided by the study sponsor or research team.

Almıla G Pamuk, Doç. Dr.

CONTACT

[email protected]

9005335296325 ext. 03123051207

muhammed r hız, research assistant

CONTACT

[email protected]

9005417800327 ext. 9003123051207

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Ultrasound Measurement of Skin to Epiglottis Distance for Prediction of Difficult Airway in Adult Patients

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 27, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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