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NCT Number: NCT06733766

Ultrasound-guided Thermal Ablation for Recurrent Thyroid Cancer

To evaluate the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer

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Key information

Conditions

Recurrent Thyroid Cancer Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases Thyroid Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location status: Recruiting

Location contact

Lin Yan

CONTACT

Lin Yan

PRINCIPAL_INVESTIGATOR

About this study

To evaluate and predict the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer by a multicenter study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient received thyroidectomy for thyroid cancer
  • recurrent lesions were pathologically proven to be malignant by core-needle biopsy or fine needle aspiration
  • no evidence of distant metastases.
  • follow-up period ≥12 months

Exclusion criteria

  • coagulation disorder, serious heart, respiratory, liver, or renal failure
  • dysfunction of the vocal cord on the opposite side

Treatment and study plan

ultrasound-guided thermal ablation

Procedure

microwave ablation, radiofrequency ablation, laser ablation

Primary outcomes

  1. rate of disease progression

    Time frame: through study completion, an average of 6 months

    cervical lymph node metastases and persistent tumors confirmed by pathology, Distant metastasis detected by CT, positron emission tomography, or bone scan if there were suspicious symptoms.

Secondary outcomes

  1. rate of complications

    Time frame: 1 week

    complication of ablation

  2. rate of volume reduction

    Time frame: through study completion, an average of 6 months

    volume reduction of tumor after ablation on ultrasound and contrast-enhanced ultrasound

  3. rate of tumor disappearance

    Time frame: through study completion, an average of 6 months

    complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound

  4. Tg level

    Time frame: through study completion, an average of 6 months

    serum thyroglobulin level

  5. rate of delayed surgery

    Time frame: through study completion, an average of 1 year

    patients underwent surgery after ablation because of anxiety

Study contacts

Contact information is provided by the study sponsor or research team.

Lin Yan

CONTACT

[email protected]

13811237313 ext. 86

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

Ultrasound-guided Thermal Ablation for Recurrent Thyroid Cancer: A Multicenter Study

Important dates

Study start
2024
Primary completion
2028
Study completion
2030
First posted
Dec 13, 2024
Registry last updated
Feb 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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