Cleveland Clinic
Cleveland, Ohio, 44195, United States
NCT Number: NCT00825786
This study will test the hypothesis that sequential injection of 1.5% mepivacaine followed 90 seconds later by 0.5% ropivacaine in ultrasound guided supraclavicular block provides a quicker onset and a longer duration of analgesia than an equi-dose mixture of the two local anesthetics.
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Notify Me18 year–70 year
All sexes
Interventional
Phase 3
Cleveland, Ohio, 44195, United States
Patients will be randomized into one of two groups, Group M: Ropivacaine and Mepivacaine - subject will receive two injections before surgery begins. These two injections will consist of the mixture of mepivacaine (15 ml) and ropivacaine (15 ml).
Group S: Mepivacaine followed by Ropivacaine. Subjects will receive two injections before surgery begins. One injection will contain mepivacaine (15 ml) and the other will contain ropivacaine (15 ml).
On the first, second, and third mornings after surgery,subjects will be asked to rate their pain on a scale of 1 to 10. If the subject is discharged from the hospital, a telephone call will be made to the subject's home to collect this information.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
ropivacaine (15 ml).
One syringe will contain mepivacaine (15 ml)
Time frame: During surgery: postoperative day 0
The primary outcomes will be the onset time, onset of surgical block, and duration of analgesia.
Time frame: during surgery from induction time to end case time
Time frame: during surgery
Time frame: through post operative day 3
The severity of postoperative pain was assessed by an observer blinded to treatment using a 0- to 10-point verbal response score (VRS): 0 = no pain and 10= worst pain
Time frame: through post operative day 3
The severity of postoperative pain was assessed by an observer blinded to treatment using a 0- to 10-point verbal response score (VRS): 0 = no pain and 10 = worst
Time frame: from surgery date to postoperative day 1
Time from the complete onset of sensory block until first request for an analgesic
Time frame: postoperative day 1 to day 3
In morphine equivalent dose
The Cleveland Clinic
Other
Ultrasound Guided Supraclavicular Nerve Block: Comparison Between a Mixture of Mepivacaine and Ropivacaine, and Sequential Injection of Mepivacaine Followed by Ropivacaine
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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