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OpenTrials
Completed

NCT Number: NCT06913348

Ultrasound-Guided Sciatic Popliteal Nerve Block vs. Erector Spinae Plane Block in Endovascular Management of CLI

Comparison of popliteal sciatic nerve block and erector spinae plane block (ESPB) in patients undergoing endovascular management of critical lower limb ischemia (CLI).

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Key information

About this study

Nerve blocks, particularly regional anesthesia techniques, have been increasingly used in the endovascular management of critical lower limb ischemia (CLI). These techniques offer numerous advantages over general and local anesthesia.

Primary Advantages of Nerve Blocks:

  • Superior Pain Control

Nerve blocks, such as femoral and sciatic nerve blocks, provide effective pain relief by anesthetizing the nerve supply to the lower limb.

They offer more comprehensive analgesia than local anesthesia alone, as they numb the entire area around the puncture site.

  • Enhanced Patient Comfort

Nerve blocks allow patients to remain pain-free during and after the procedure.

They minimize discomfort even in lengthy or complex cases.

  • Reduction in Systemic Analgesic Requirements

By providing localized anesthesia, nerve blocks significantly reduce the need for systemic analgesics, particularly opioids.

This is essential because CLI patients often have comorbidities that make opioid use risky.

  • Fewer Opioid-Related Side Effects

Nerve blocks reduce the incidence of opioid-related side effects, including nausea, vomiting, respiratory depression, and sedation.

  • Improved Hemodynamic Stability

Nerve blocks preserve autonomic nervous system function, reducing fluctuations in blood pressure and heart rate compared to general anesthesia.

This is especially beneficial for CLI patients, who frequently have underlying cardiovascular disease.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient age will be 20-70 years.
  • Patients will be diagnosed with critical lower limb ischemia by clinical presentations and investigations.
  • ASA physical status 2-3

Exclusion criteria

  • Patient refusal to participate in this study.
  • Patient inability to understand the scales or to describe to the investigators.
  • Coagulation disorder.
  • Sever renal or kidney dysfunction.
  • Taking opioids before admission.
  • Morbid obesity .

Treatment and study plan

Popliteal Sciatic nerve block

Procedure

Procedure/Surgery: Patients will receive either an ultrasound-guided sciatic popliteal nerve block or an ultrasound-guided erector spinae plane block for anesthesia during endovascular management of critical lower limb ischemia.

Primary outcomes

  1. Block quality

    Time frame: Baseline (immediately after block administration).

    Assessment of the occurrence of complete motor and sensory block.

Secondary outcomes

  1. Postoperative Analgesia Duration

    Time frame: Up to 24 hours postoperatively.

    Time from block administration to the first request for rescue analgesia.

    .

Sponsors and collaborators

Lead sponsor

Minia University Hospital

Other

Registry information

Official study title

Ultrasound-Guided Sciatic Popliteal Nerve Block vs. Erector Spinae Plane Block in Patients Undergoing Endovascular Management of Critical Lower Limb Ischemia

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Apr 6, 2025
Registry last updated
Apr 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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