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NCT Number: NCT06588777

Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

This study aims to compare the efficacy of using Ultrasound guided modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) versus quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy under general anesthesia.

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Key information

Age range

21 year–71 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ainshams university hospitals

Cairo, Egypt

Location status: Recruiting

Location contact

Ainshams

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aging ≥ 21 years to ≤ 70 of both sexes.
  • Patients undergoing Laparoscopic cholecystectomy surgeries.
  • ASA physical status classes I - II.

Exclusion criteria

  • Patient's refusal of procedure or participation in the study.
  • ASA classes III or above.
  • Coagulopathy and bleeding disorders.
  • Evidence of Local skin infections at site of injection.
  • Body mass index >40kg/m2
  • A history of relevant local anesthetic allergy.

Treatment and study plan

Modified Thoracoabdominal Nerve Block through perichondrial approach (M-TAPA)

Procedure

transversus abdominis, internal oblique, and external oblique muscles will be identified with a high-frequency (10 MHz) linear probe on the costochondral angle in the sagittal plane under ultrasound guidance at the 10th costal margin. A deep angle was given to the costochondral angle at the edge of the 10th costal margin with the probe in the sagittal direction to view the lower surface of the costal cartilage in the midline. A 22-G, 100-mm block needle will be inserted in the cranial direction using the in-plane technique and the needle tip will be moved to the posterior aspect of the 10th costal cartilage. It is noted that the needle tip never crossed the cranial edge of the 10th costal cartilage

Other names: (M-TAPA)

quadratus lumborum block

Procedure

using ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA) and a curved ultrasound probe (2.5-7.5 MHz). The probe will be placed in the mid-axillary line between the lower costal margin and the iliac crest in a transverse plane to view all abdominal layers. The probe will be moved towards the posterior axillary line, to reach a point where all three abdominal muscle layers merge to form aponeurosis.

The aponeurosis will then be followed dorsally until the quadratus lumborum muscle is seen deep to transversalis fascia with its attachment to the transverse process of the L4 vertebral body. A 22 G, 100 mm, blunt, insulated nerve block needle will be inserted 1 cm medial to the probe and advanced using the in-plane technique with ultrasound real-time assessment. The injection site will be the junction of transversalis fascia and the anterolateral border of quadratus lumborum muscle

Other names: (QLB)

Primary outcomes

  1. Time to first Rescue Analgesia

    Time frame: 24 hours postoperative

    Is to measure the first time to resque analgesia postoperative (24 hours)

Secondary outcomes

  1. The total requirements of rescue analgesia Meperidine (pethidine) over the first 24 hours postoperative

    Time frame: 24 hours postoperative

  2. Heart rate

    Time frame: at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively

  3. Blood pressure

    Time frame: at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively

  4. Spo2 measuring

    Time frame: at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Hassan, Master

CONTACT

[email protected]

01158195158

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 19, 2024
Registry last updated
Sep 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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