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Completed

NCT Number: NCT01305603

Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic

Using Magnetic resonance (MR) scanning and ultrasonography the investigators wish to investigate, in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

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Key information

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Bispebjerg Hospital, Copenhagen University Hospital

Copenhagen, Capital Region of Denmark, 2400, Denmark

About this study

There has been much debate as to what extent the classical TAP block will anesthetize more than the frontal dermatomes (TH10-Th12/L1). Some cadaver studies have been performed with injection of dye in the classical TAP. However, it is still not clear whether a single injection of local anesthetic in the classical TAP block position will reach the more cephalad and medial intercostal TAP plexus (Th6-Th9). In this study the investigators use MR scanning and ultrasonography to investigate in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy male
  • 18 years old or more
  • had no previous abdominal surgery
  • no regular medication
  • no coagulation disorders
  • no claustrophobia

Exclusion criteria

  • if the volunteer is not able to accept an uncomplicated administration of a classical (single) or dual TAP block

Treatment and study plan

Bupivacaine

Drug

On both sides of the abdomen 30 ml of bupivacaine 2.5 mg/ml will be injected. This is a total of 60 ml of bupivacaine 2.5 mg/ml.

Other names: Local anesthetic

Injection

Procedure

Injection under ultrasound-guidance

Other names: Nerve blocks

Primary outcomes

  1. Distribution of local anesthetic evaluated by MR scanning

    Time frame: 30 minutes after administering the TAP blocks

Secondary outcomes

  1. Spread of anesthetized frontal dermatomes

    Time frame: 30 minutes after administering the TAP blocks

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Registry information

Official study title

Dual TAP Block Characteristics - Evaluation of Local Anesthetic Distribution by MR Scanning

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Mar 1, 2011
Registry last updated
Apr 11, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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