Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study

The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance cardiovascular risk prediction beyond NORRISK-2

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Key information

Conditions

Cardiovascular Diseases Arterial Occlusive Diseases Arteriosclerosis Atheroscleroses Atherosclerosis Atherosclerosis of Femoral Artery Brain Diseases Carotid Artery Diseases Carotid Artery Plaque Carotid Stenosis Central Nervous System Diseases Cerebrovascular Disorders Digestive System Diseases Fatty Liver Heart Diseases Ischemic Cardiovascular Disease Ischemic Stroke Liver Diseases Myocardial Ischemia Nervous System Diseases Stroke Vascular Diseases

Age range

45 year–74 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Austad Diagnostikk

Oslo, East, 0366, Norway

About this study

Design: The P-SONAR Study is a prospective cohort study of all men and women aged 45-74 years attending a health check at one of 10 ultrasound clinics in Norway.

Time schedule: Study inclusion and baseline examinations took place in the period April 2022- March 20025.

Current status: Ultrasound follow-up examinations take place from January 2025 - December 2029.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Persons attending a health check during the study period.

Exclusion criteria

If they do not consent to participate

Treatment and study plan

Primary outcomes

Carotid and femoral plaque burden cardiovascular (CV) predictive ability beyond NORRISK-2

Time frame: From enrollment to an average of 10 years

Additative ability of carotid and femoral plaque burden assessed by ultrasound to predict incident cardiovascular events, beyond conventional risk factors by NORRISK-2
May plaque burden predict incident cardiovascular disease.

Time frame: From enrollment to an average of 10 years.

Find best cutoff value of wTPT plaque burden to predict incident CV disease, across different age groups and sex.

Sponsors and collaborators

Lead sponsor

University Hospital, Akershus

Other

Collaborators

University of Oslo

Registry information

Official study title

Ultrasound of Carotid and Femoral Plaque Burden and Non-alcoholic Fatty Liver Disease as Predictors of Cardiovascular Disease

Acronym: P-SONAR

Important dates

Study start: 2022
Primary completion: 2025
Study completion: 2025
First posted: Apr 18, 2025
Registry last updated: Apr 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed