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NCT Number: NCT01304420

Ultrasonography in Juvenile Idiopathic Arthritis

The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.

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Key information

Conditions

Juvenile Idiopathic Arthritis, Oligoarthritis Arthritis Arthritis, Juvenile Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Polyarticular Juvenile Rheumatoid Arthritis Rheumatic Diseases Skin and Connective Tissue Diseases Systemic Juvenile Idiopathic Arthritis

Age range

5 year–15 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Pediatric research dept, Aarhus Universityhospital, Skejby

Aarhus, Region Midt, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Juvenile idiopathic arthritis: Oligoarticular, polyarticular or systemic onset type.
  • Informed consent from parents
  • between 5-15 years of age

Exclusion criteria

  • Other diagnoses that involves bones or cartilage
  • Intraarticular steroid injections within 1 month of the trial investigation

Treatment and study plan

Ultrasonography

Device

Scanning 5 joints bilaterally with an ultrasound scanner

Other names: Hitachi EUB-7500

Primary outcomes

  1. Joint cartilage thickness

    Time frame: 1.5 years

    Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist

Secondary outcomes

  1. Level of different biomarkers in serum and urine

    Time frame: 1.5 years

    Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Aarhus University Hospital

Registry information

Official study title

Changes in Joint-Cartilage as a Measure of Outcome in Juvenile Idiopathic Arthritis - Assessed by Ultrasonography and Biomarkers

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Feb 25, 2011
Registry last updated
Mar 22, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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