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NCT Number: NCT07293949

Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury

Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via ultrasound), functional status, spasticity, and ambulation levels.

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Key information

Conditions

Spinal Cord Injuries (SCI) Arthritis Central Nervous System Diseases Joint Diseases Musculoskeletal Diseases Nervous System Diseases Osteoarthritis Osteoarthritis (OA) Rheumatic Diseases Spinal Cord Diseases Spinal Cord Injuries Trauma, Nervous System Wounds and Injuries

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Gaziosmanpasa Training and Research Hospital

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18 to 60 years,
  • Cervical, thoracal or lumber level of spinal cord injury
  • AIS (American Spinal Injury Association Impairment Scale) Level A, B, C, or D
  • Assisted ambulation of any kind
  • Literacy
  • Giving oral and written consent to participate in the study

Exclusion criteria

  • Patients with sacral level injury
  • AIS E
  • MAS 4 level of spasticity
  • History of any lower extremity operation
  • History of fracture
  • Botulinum toxin injection in the last 6 months
  • Existing diagnosis of any rheumatologic or endocrine diseases

Treatment and study plan

Primary outcomes

  1. Talar cartilage thickness

    Time frame: Baseline

    The talar cartilage of both lower extremities are to be assessed with ultrasound

Secondary outcomes

  1. Functional Independence Measure (FIM) score

    Time frame: Baseline

    Functional Independence Measure scores will be held for the patient group in order to assess functional independence. This 18-item scale ranges between 18-126, higher scores indicating better outcomes.

  2. Modified Ashworth Scale (MAS)

    Time frame: Baseline

    The spasticity level of patients are to be recorded for both ankle flexor and extensors via Modified Ashworth Scale. This scale ranges from 0 to 4; 0 indicating no spasticity, and 4 indicating severe increase in muscle tone with rigid joint.

  3. Walking Index for Spinal Cord Injury II (WISCI II)

    Time frame: Baseline

    Ambulatory status of the patients will be recorded with this measuring scale, ranging between 0 (non ambulatory) to 20 (able to walk 10 meters with no devices/orthosis/assistance).

Sponsors and collaborators

Lead sponsor

Gaziosmanpasa Research and Education Hospital

Other Gov

Registry information

Official study title

Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury: A Cross-Sectional Case-Control Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 19, 2025
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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