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OpenTrials
Completed

NCT Number: NCT06651762

Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries

Total Knee Replacement surgery is common procedure that is usually done for patients suffering from persistent pain with limitation of movement. Unfortunately, they do suffer after the operation as it is associated still with significant pain that affect the rehabilitation plan, hospital length of stay, life style and patient satisfaction. New approaches are rising every day to add to the multimodal management plan. Genicular nerves cooled radiofrequency ablation is a new approach that can be simply done U.S. guided with little side effects, if any, and great results.

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Key information

Conditions

Osteoarthritis of Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

faculty of medicine Ain Shams University

Cairo, 02, Egypt

About this study

the study measures the efficacy of genicular nerves cooled radiofrequency ablation in enhancing quality of rehabilitation in patients undergoing total knee replacement

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Undergoing a scheduled unilateral total knee replacement surgery

-

Exclusion criteria

  • • Allergy to any of the drugs used in the study
  • Alcohol or drug abuse
  • Psychiatric disease

Treatment and study plan

unilateral Radiofrequency

Procedure

unilateral genicular nerve cooled radio frequency ablation pre-operative

bilateral Radiofrequency

Procedure

bilateral genicular nerve cooled radio frequency ablation pre-operative

Epidural

Procedure

Patients will receive epidural anesthesia intra operative and epidural analgesia post-operative

Primary outcomes

  1. o Epidural rescue doses

    Time frame: 1st 48 hours

    rescue doses reflects degree of pain control

Secondary outcomes

  1. WOMAC score

    Time frame: baseline preoperative, and the at 2, 6 and 12 weeks postoperative

    assessment of the functional state of the patient and degree of pain and limitation of movement

  2. Knee range of motion

    Time frame: Assessed weekly for 3 weeks postoperatively (Weeks 1, 2, and 3)

    Time to achieve full knee range of motion will be assessed by measuring active knee flexion and extension in degrees (°) using a universal goniometer during weekly postoperative assessments. The outcome will be reported as the number of days or weeks required to achieve full range of motion, as defined in the study protocol.

  3. Postoperative inflammatory signs assessed by clinical examination

    Time frame: Assessed weekly for 3 weeks postoperatively (Weeks 1, 2, and 3).

    Postoperative inflammatory signs, including redness (erythema), local warmth, and swelling around the operated knee, will be assessed by clinical examination. Each sign will be recorded as present or absent. The outcome will be reported as the number of participants with each inflammatory sign at each assessment.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Oct 22, 2024
Registry last updated
Aug 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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