Ultra-early Chest CT for SAP Prediction

Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.

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Key information

Conditions

Acute Ischaemic Stroke Stroke-associated Pneumonia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Suzhou Municipal Hospital of Anhui Province, Suzhou, Anhui, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients aged ≥18 years;
Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
Had chest CT performed within 24 hours of stroke onset.

Exclusion criteria

Pneumonia;
Chest CT images unavailable or incomplete for assessment;
Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset

Treatment and study plan

Primary outcomes

Stroke-associated pneumonia

Time frame: within 7 days after stroke onset

SAP was defined as pneumonia occurring within 7 days after stroke onset. Potential events were screened using discharge diagnosis codes and medical record documentation, and then confirmed by manual chart review using prespecified clinical, laboratory, and radiological criteria consistent with the Pneumonia in Stroke Consensus Group and modified CDC definitions.

Sponsors and collaborators

Lead sponsor

Capital Medical University

Other

Registry information

Official study title

Ultra-early Chest CT Improves Risk Prediction of Stroke-associated Pneumonia: Model Development and External Validation in a Multicentre Retrospective Study

Acronym: SENTRY

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jan 7, 2026
Registry last updated: Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed