UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)

Inclusion criteria

• Agreement to participate in the study
• 60-89 years of age
• Diagnostic criteria for Mild Cognitive Impairment diagnosis: subjective memory complaints, Montreal Cognitive Assessment score of <26, intact instrumental activities of daily living (Smith et al., 1996) OR subjective age-associated memory complaints
• Cohabitation with an adult capable of ensuring correct usage of the physical activity monitors during the study and verifying self-reports of activity levels.
• Adequate visual and auditory acuity to allow neuropsychological testing.
• Screening laboratory tests and EKG without significant abnormalities that might interfere with the study. If screening laboratory tests or EKG show abnormalities, PI may request clearance from primary care physician before subject continues in study.

Exclusion criteria

• Comorbid conditions impacting mobility
• Current, untreated depression: BDI-II score >13
• Diagnosis of probable Alzheimer's disease (AD) or any other dementia (e.g., vascular, Lewy body, frontotemporal).
• Evidence of other neurological or physical illness that can produce cognitive deterioration. Volunteers with a history of head trauma, stroke, TIA, carotid bruits, or lacunes on MRI scans will be excluded.
• Contraindication to the MRI including claustrophobia, metal in body, surgery within 60 days, certain medical implants or previous abnormal MRI results.
• History of cardiovascular disease
• Uncontrolled hypertension (systolic BP > 170 or diastolic BP > 100)
• Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria (APA, 2000), including current alcoholism or substance addiction.
• Current use of marijuana
• Previous use of marijuana for at least 15 days in a month, initiating use during adolescence and continuing for at least one year