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Completed

NCT Number: NCT00685867

Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel).

The primary objective is to determine the effect of an early MRSA detection & decolonization & isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

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Key information

Conditions

MRSA Infection Bacterial Infections Bacterial Infections and Mycoses Gram-Positive Bacterial Infections Infections Staphylococcal Infections

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Geneva University Hospitals

Geneva, 1211, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Surgical patients with LOS>24h

Exclusion criteria

  • Surgical patients with LOS<24h

Treatment and study plan

Rapid molecular MRSA test

Other

PCR-based rapid screening for MRSA carriage

Hand hygiene promotion

Behavioral
  • Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance
  • Standard precautions (e.g. use of gloves for contacts with wounds and body fluids)
  • Isolation precautions according to the hospitals' capacity and strategy
  • Additional basic infection control interventions (if necessary)

Primary outcomes

  1. Nosocomial MRSA isolation rate (expressed as the monthly rate of MRSA in clinical isolates divided by the number of susceptible patients per hundred)

    Time frame: Monthly

Secondary outcomes

  1. Nosocomial MRSA infection rate (= number of nosocomial MRSA infections per 100 admissions)

    Time frame: Monthly

Sponsors and collaborators

Lead sponsor

University Hospital, Geneva

Other

Collaborators

  • European Commission

Registry information

Official study title

An Interventional Study to Evaluate the Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients

Acronym: MOSAR-04

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
May 29, 2008
Registry last updated
Aug 21, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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