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NCT Number: NCT06624319

Two Doses of Dexmedetomidine as Adjuvent to Bupivacaine in Tap Block

The aim of this study to determine the optimal dose of dexmedetomidine as an adjuvant to bupivacaine in U.S guided TAP block for preemptive analgesia In patients undergoing lower abdominal cancer surgeries.

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Key information

Conditions

Post Operative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The transversus abdominis plane (TAP) involves innervations of the anterolateral abdominal wall derived from T6-L1. The block can be given either by anatomical landmark technique or by using an ultrasound probe. The local anesthetic is deposited in a plane between internal oblique and transversus abdominis muscle. It provides adequate postoperative analgesia following various abdominal surgeries.Dexmedetomidine is an alpha-2 agonist that has been approved as a venous sedative and an adjuvant for pain relief .In previous studies, the addition of dexmedetomidine to bupivacaine in the TAP block has prolonged the effect of this block . So far, the optimal dose of dexmedetomidine for the TAP block has not been determined.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age from 18 to 65 years old
  • lower abdominal cancer surgery

Exclusion criteria

  • patient refusal
  • the local anesthetic allergy
  • coagulopathy
  • local infection at the procedure site
  • psychic patients
  • patient on chronic opioid use

Treatment and study plan

Dexmedetomidine as adjuvent to bupvacaine in tap block

Drug

The analgesic effect of Two different doses of dexmedetomidine as adjuvent to bupivacaine in tap block

Other names: Precedex

Primary outcomes

  1. Total morphine consumption during the first 24 hours postoperatively

    Time frame: First 24 hours postoperative

    Morphine consumption during the First 24 hours postoperative

Secondary outcomes

  1. Severity of pain using Visual analogue scale

    Time frame: First 24 hours postoperative

    The severity of pain at rest and on coughing will be assesd using a 10-cm vas(0 means no pain ,10 means worst pain)

  2. Patient level of sedation using four point modified ramsy scale

    Time frame: First 24 hours postoperative

    using a 4-point scale (0 = awake and alert, 1 = minimally sedated, responds to speech, 2 = moderately sedated, arousable by tactile stimulation, and 3 = deeply sedated, arousable only by painful stimulation)

Study contacts

Contact information is provided by the study sponsor or research team.

Kerolos S Tawfeek, Resident

CONTACT

[email protected]

+2001551990411

Mohanad A Mohamed

CONTACT

[email protected]

+2001027068866

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Comparing the Analgesic Effect of Two Different Doses of Dexmedetomidine Added to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgeries; A Randomized Clinical Trial

Acronym: Dexmed/tap

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 2, 2024
Registry last updated
Oct 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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