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Completed

NCT Number: NCT01792063

Two Different Preparations of Sevoflurane in Induction

In our study we aim to study the effects of two preparations of Sevoflurane in vital capacity rapid inhalation induction.

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Key information

Conditions

Coughing on Induction Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Vapors; Inhalation

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department

Istanbul, Fatih, 34400, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing abdominal surgery

Exclusion criteria

  • Patients with any cardiovascular or respiratory disease, usage of any kind of sedative drug, expected airway difficulty and obese patients (BMI>35) will be excluded from the study

Treatment and study plan

Sevoflurane

Drug

Other names: Sevorane, Abbott Laboratories

Primary outcomes

  1. effect of different preparations of sevoflurane on Induction on hypnosis time

    Time frame: 1 hour

    Induction for anesthesia will be achieved with sevoflurane A and Sevoflurane B in total of 100 randomized (American Society of Anesthesiology status I-II) patients undergoing abdominal surgery. During the induction patients will be asked to breath as deep as possible and then hold their breaths to the point where they cannot anymore and flexing their right arm. Occurrence of hypnosis will be confirmed with both the loss of eyelash-reflex and failing of flexed-holding arm. Time and number of breaths needed for the loss of consciousness will be noted. Existence of hiccup, cough, increase in secretions, and refusal of the mask by the patient will be reported if any. All patients will be extubated and released to the ward after they are questioned about any discomfort or issue they want to report to anesthesiologist

Secondary outcomes

  1. effect of different sevoflurane preparations on hemodynamics

    Time frame: 1 hour

    After the induction and occurrence of hypnosis, Systemic arterial pressure (SAP) values will be noted. Tracheal intubation will be performed and post-intubation SAP values will be noted. The SAP values will noted in the 5th minute of the induction.

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

A Randomized Clinical Trial on the Efficiency, Hemodynamic Effects and Patient Comfort of Two Different Preparations of Sevoflurane After Vital Capacity Rapid Inhalation Induction

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Feb 15, 2013
Registry last updated
Apr 19, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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