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Active, Not Recruiting

NCT Number: NCT02515760

Tumor-specific T Cells in Lung Cancer

Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Non-small Cell Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Division of Thoracic Surgery, Technical University of Munich, Munich, Germany

Munich, 81675, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with histology proven non-small cell lung cancer or a lesion suspicious of non-small cell lung cancer (lung cancer group)
  • Healthy donors (control group)
  • written informed consent

Exclusion criteria

  • Autoimmune disease
  • Patients receiving immunomodulatory drugs, e.g. tacrolimus
  • Prior malignancy
  • Pregnancy

Treatment and study plan

Bone marrow aspiration from the iliac crest

Procedure

Illinois bone marrow aspiration neddle

Device

Primary outcomes

  1. Frequencies of tumor-specific T cells

    Time frame: 2 weeks postoperative

    % of all T cells

Secondary outcomes

  1. Tumor-specific T cells location determined by Enzyme Linked Immuno Spot Assay (ELISPOT) analysis of peripheral blood and bone marrow samples from the same patient

    Time frame: 2 weeks postoperative

    location: peripheral versus bone marrow

  2. Long-term survival

    Time frame: 5 years postoperative

    OS

Sponsors and collaborators

Lead sponsor

University Hospital Heidelberg

Other

Collaborators

  • German Cancer Research Center
  • Heidelberg University

Registry information

Official study title

Tumor-specific Effector T Cells in Non-small Cell Lung Cancer

Important dates

Study start
2014
Primary completion
2018
Study completion
2025
First posted
Aug 5, 2015
Registry last updated
Dec 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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