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Completed

NCT Number: NCT05448339

Tumor Feeding Vessels Deprivation Combined With Tyrosine Kinase Inhibitor in Liver Transplantation

To investigate the value of tumor feeding vessels deprivation combined with tyrosine kinase inhibitor in liver transplantation. Patients are enrolled into two groups according to the downstaging therapy they undergo before transplantion.

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Key information

Conditions

Liver Transplantation

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai General Hospital

Shanghai, Shanghai Municipality, 200000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

(1) age ≥18 years; (2) exceeding UCSF criteria; (3) absence of vascular invasion, nodal involvement, or extrahepatic metastases; (4) receiving TACE treatment or LTFVD treatment for downstaging purposes.

Treatment and study plan

PVHA or TACE

Combination Product

PVHA or TACE

Primary outcomes

  1. Underwent LT

    Time frame: January 2013 and December 2020

    Underwent LT

  2. Successful downstaging

    Time frame: January 2013 and December 2020

    Successful downstaging

Secondary outcomes

  1. AFP reduction of patients

    Time frame: January 2013 and December 2020

    AFP reduction of patients

  2. Survival time of patients

    Time frame: January 2013 and December 2020

    Survival time of patients

  3. Recurrence of patients

    Time frame: January 2013 and December 2020

    Recurrence of patients

Sponsors and collaborators

Lead sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Other

Registry information

Official study title

The Value of Tumor Feeding Vessels Deprivation Combined With Tyrosine Kinase Inhibitor in Liver Transplantation

Important dates

Study start
2013
Primary completion
2023
Study completion
2024
First posted
Jul 7, 2022
Registry last updated
Jan 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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