Tumor Deposits in Colorectal Cancer and Its Prognostic Value in Survival and Metastasis

This study aims to evaluate the tumor deposits in colorectal cancer and its prognostic value in survival and metastasis

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Key information

Conditions

Tumor Deposits Colonic Diseases Colorectal Cancer Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Extranodal Extension Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Metastasis Neoplasm Metastasis Neoplasms Neoplasms by Site Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Prognosis Rectal Diseases Survival

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Minia University

Minya, Minya Governorate, 61611, Egypt

About this study

Tumor deposits (TDs) are defined as isolated tumor foci found in the pericolonic or perirectal fat or the adjacent mesentery (mesocolonic fat) away from the invasive margin of the tumor without evidence of residual lymphatic tissue. TDs are significantly correlated with poor prognosis after colorectal cancer surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age above 18 years old.
Both sexes.
All Colorectal cancer patients From Stage I to III Colorectal cancer with pathologically positive Tumor deposits.

Exclusion criteria

Patient took neoadjuvant therapy.
No information available on tumor deposits.
Colorectal cancer is not the only primary cancer.
Patients with incomplete information about follow-up.

Treatment and study plan

Therapeutic resection

Procedure

Patients with colorectal cancer underwent therapeutic resection with pathologically positive tumor deposits (TDs) to determine distant metastasis occurrence and the effect of TDs on survival.

Primary outcomes

Patients' overall survival

Time frame: 2 years postoperatively

Patients' overall survival (OS) is defined as from colorectal cancer (CRC) diagnosis to death.

Secondary outcomes

Distant metastasis

Time frame: 2 years postoperatively

Distant metastasis is defined as the presence of liver, lung, bone, or brain metastases during or after colorectal cancer (CRC) diagnosis.

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2025
First posted: Mar 19, 2025
Registry last updated: May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed