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Completed

NCT Number: NCT02578212

Trust Game and Placebo Response

In the proposed study, investigators aim to investigate the role of interpersonal trust in the conditioned placebo analgesia process with healthy male subjects in a standardized experimental heat pain paradigm.

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Key information

Conditions

Placebo Effect Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Trust

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Basel

Basel, 4055, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men: age between 18 and 40 years old
  • Healthy by self-report statement, thus no known current or chronic somatic diseases or psychiatric disorders
  • Right-handedness (Oldfield, 1971)
  • Willing to participate in study

Exclusion criteria

  • Any acute or chronic disease (chronic pain, hypertension, heart disease, renal disease, liver disease, diabetes) as well as skin pathologies, neuropathies or nerve entrapment symptoms, sensory abnormalities affecting the tactile or thermal modality
  • Current medications (psychoactive medication, narcotics, intake of analgesics) or being currently in psychological or psychiatric treatment
  • Insufficient German language skills to understand the instructions
  • Previous participation in studies using pain assessment (threshold and tolerance) with Peltier Devices
  • Daily consumption of more than three alcoholic standard beverages per day (a standard alcoholic beverage is defined as either 3dl beer or 1 dl wine or 2cl spirits
  • Current or regular drug consumption (THC, cocaine, heroin, etc.)

Treatment and study plan

Placebo

Other

Primary outcomes

  1. Visual analogue scale (VAS) rating (Intensity + unpleasantness of pain)

    Time frame: 2 hours

Secondary outcomes

  1. Visual analogue scale (VAS) rating (trust)

    Time frame: 2 hours

  2. State-Trait-Anxiety (STAI- X1)

    Time frame: 2 hours

  3. State Trait Anger Expression (STAXI)

    Time frame: 2 hours

  4. Questionnaire about expectations (Erwartungsfragebogen)

    Time frame: 2 hours

  5. Questionnaire about the investigator (Fragebogen zum Versuchsleiter

    Time frame: 2 hours

  6. sociodemographic questionnaire (Soziodemographischer Fragebogen (SES))

    Time frame: 2 hours

  7. Questionnaire about Self-assessment of partnership binding (Bochumer Bindungsfragebogen - BoBi)

    Time frame: 2 hours

  8. State-Trait-Anxiety (STAI-X2 )

    Time frame: 2 hours

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Oct 16, 2015
Registry last updated
Apr 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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