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Completed

NCT Number: NCT07063628

Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity

Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

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Key information

Age range

38 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Rehab Hussein Werida

Damanhūr, Elbehairah, 31527, Egypt

About this study

A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD.

Provision of privacy:

Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations.

Informed consent:

Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study.

Methods: Study patients and procedures:

Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery

All the participants were subjected to following:

  • History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension.
  • Physical examination including height, weight and waste circumference
  • Resing 12 leads ECG
  • Laboratory investigations:
  • Fasting blood glucose (FBG)
  • Triglyceride (TG), TG index.
  • Total Cholesterol level
  • Renal Function test . Echocardiographic evaluation
  • Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of CAD with ≥50% stenosis in at least one major coronary artery.

Exclusion criteria

  • Patients with acute coronary syndrome, arrhythmias, previous coronary interventions (PCI or CABG), or inability to undergo echocardiographic assessment.

Treatment and study plan

TyG-derived index.

Diagnostic Test

Derived indices included:

  • Ty,G×B,M,I = TyG index × body mass index
  • TyG×W,C = TyG index × waist circumference
  • TyG×WH,tR = TyG index × waist-to-height ratio Quartile-based stratification was applied to each TyG-derived index.

Other names: TG index

Left Ventricular Speckle Tracking

Diagnostic Test

Coronary Angiography and Gensini Scoring: All participants underwent standard diagnostic coronary angiography. CAD was categorized as one-, two-, or three-vessel disease based on the number of vessels with ≥50% stenosis. The severity of CAD was quantified using the Gensini score, which assigns a severity weight to each lesion depending on degree of stenosis and anatomical location. Final scores were calculated by summing weighted values across all coronary segments.

Other names: Echocardiographic Assessment

Primary outcomes

  1. triglyceride-glucose (TyG) index

    Time frame: 2 months

    predictive value of the triglyceride-glucose (TyG) index and its modified forms (TyG×BMI, TyG×WC, TyG, ×, W,Ht,R ) with global longitudinal strain (GLS) in assessing coronary artery disease (CAD) severity, as quantified by the Gensini score.

  2. longitudinal strain (GLS)

    Time frame: 2 months

    Echocardiography parameter in assessing coronary artery disease (CAD) severity

  3. Gensini score.

    Time frame: 2 months

    Score assessing coronary artery disease (CAD) severity

Sponsors and collaborators

Lead sponsor

Damanhour University

Other

Collaborators

  • Tanta University

Registry information

Official study title

Comparative Assessment of Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity: Insights From Gensini Scoring

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 14, 2025
Registry last updated
Jul 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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