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NCT Number: NCT07569302

Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger

The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36 hours before oocyte retrieval ] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.

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Key information

Conditions

Infertility (IVF Patients) Genital Diseases Infertility Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

Bedaya Hospital

Giza, Giza Governorate, 3753303, Egypt

Location contact

Amira Alasmar, M.D, PhD

PRINCIPAL_INVESTIGATOR

Usama M Fouda, Prof

CONTACT

[email protected]

+201095401375

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • GnRH antagonist IVF cycle
  • Normo-responders to induction of ovulation

Exclusion criteria

  • Hypogonadotrophic hypogonadism
  • Endometriosis
  • History of recurrent abortion

Treatment and study plan

Modified dual trigger

Drug

HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up.

HCG

Drug

HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.

Primary outcomes

  1. Metaphase-II oocytes rate

    Time frame: Ten to fifteen days after starting ovarian stimulation

    Number of MII oocyte/ number of cumulus oocyte complex

Secondary outcomes

  1. Clinical pregnancy rate

    Time frame: Five weeks after embryo transfer

    Presence of intrauterine gestational sac detected by transvaginal ultrasound

  2. Ongoing pregnancy Rate

    Time frame: Eighteen weeks after embryo transfer

    Pregnancies continued beyond 20 weeks gestation

Study contacts

Contact information is provided by the study sponsor or research team.

Usama M Fouda, Prof

CONTACT

[email protected]

+201095401375

Sponsors and collaborators

Lead sponsor

Bedaya Hospital

Other

Registry information

Official study title

Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger . A Randomized Controlled Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 6, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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